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Gu Dongfeng

Academician of CAS
Chair Professor

Gu Dongfeng is Academician of Chinese Academy of Sciences, and Chair Professor of School of Medicine of SUSTech. He currently serves as the Vice President of China International Exchange and Promotive Association for Medical and Health Care, the Vice President of Community Health Association of China, member of the expert consultation panel of Healthy China initiative, committee member of Medical Science Department of Academic Advisory Committee of Chinese Academy of Medical Sciences. Dr. Gu was former Acting Vice President of Southern University of Science and Technology (SUSTech), former Deputy Director of National Center for Cardiovascular Diseases, and former Vice President of Fuwai Hospital Chinese Academy of Medical Sciences. He obtained his bachelor’s degree of medicine in Nanjing Medical University in 1983, master degree of medicine and PhD degree in 1986 and 2007 respectively in Peking Union Medical College. He was a visiting scholar from 1990 to 1992, in Department of Epidemiology, University of Minnesota, USA, a visiting scholar in University of Toronto, Canada in 1997, and also as a visiting professor in Division of Human Genetics, University of Southampton, UK from Feb, 1999 to Feb, 2000.

Dr. Gu is a professor with specialties in preventive cardiology, epidemiology, and medical genetics as well. During the past thirty years, Dr. Gu has made outstanding contributions in the area of preventive cardiology and genetic etiology for cardiovascular disease, including helping identify major causes of death and main risk factors for cardiovascular diseases in Chinese adults, developed risk prediction model of cardiovascular diseases in China, formulated guidelines for cardiovascular disease prevention and control, and led genomic risk assessment for hyperlipidemia and coronary heart disease.

He was awarded 26 national patents and two second prize award of National Science and Technology Progress Award. More than 400 SCI papers have been published, and his research results have been widely cited by domestic and international guidelines of disease prevention and control, authoritative textbooks and monographs of the World Health Organization.

 

Educational Background & Work Experience:
Jan. 1976 -- Sept. 1978  Worker of Qidong Electrical Appliance Factory in Qidong city, Jiangsu province;
Oct. 1978 -- Jul.1983    Department of Preventive Medicine, Nanjing Medicine University, Bachelor of Medicine
Aug. 1983 -- Jul. 1986   Epidemiology of Cardiovascular Diseases, Peking Union Medical College, Master of Medicine
Jul. 1986 -- May 1995    Intern / assistant / research associate/ associate professor of Fuwai Hospital Chinese Academy of Medical Sciences;
(Sept. 1990 -- Oct. 1992 Visiting scholar in the Division of Epidemiology, University of Minnesota, USA)
Jun. 1995 -- Feb. 2009   Director of Epidemiology / Population Genetics Department, Professor of Fuwai Hospital Chinese Academy of Medical Sciences, Peking Union Medical College;
(Feb. 1999 -- Feb. 2000 Visiting Professor in the Human Genetics, University of Southampton; Sept. 2003 -- Dec. 2007  Biochemistry and Molecular Biology of Institute of Basic Medical Sciences, Peking Union Medical College, Doctor of Science);
Feb. 2009 -- June 2019  Vice President, Fuwai Hospital Chinese Academy of Medical Sciences, Director/Professor, Department of Epidemiology of Fuwai Hospital Chinese Academy of Medical Sciences;
Jul. 2015 -- June 2019  Deputy Director of National Center for Cardiovascular Diseases;

Apr. 2020 – May. 2024  Acting Vice President of SUSTech.
Aug. 2019 -- to date   Chair Professor of Medical College of SUSTech.

 

Honors:
2004  The title of Young and Middle-aged Experts with Outstanding Contribution by the Ministry of Health, the People’s Republic of China;
2004  The title of National-level Expert of New Century Talent Project;
2005  Receiver of the Special Allowance from the State Council of China;
2007  First prize of Science and Technology Award of Chinese Preventive Medicine Association;
2008  First prize of Chinese Medical Science and Technology Award;
2008  Second prize of National Science and Technology Progress Award;
2009  Second prize of National Science and Technology Progress Award;
2016  Title of National Excellent Scientist.


Recent Publications:

1.    Lu X, Liu Z, Cui Q, Liu F, Li J, Niu X, Shen C, Hu D, Huang K, Chen J, Xing X, Zhao Y, Lu F, Liu X, Cao J, Chen S, Ma H, Yu L, Wu X, Wu X, Li Y, Zhang H, Mo X, Zhao L, Huang J, Wang L, Wen W, Shu XO, Takeuchi F, Koh WP, Tai ES, Cheng CY, Wong TY, Chang X, Chan MY, Gao W, Zheng H, Chen K, Chen J, He J, Tang CS, Lam KSL, Tse HF, Cheung CYY, Takahashi A, Kubo M, Kato N, Terao C, Kamatani Y, Sham PC, Heng CK, Hu Z, Chen YE, Wu T, Shen H, Willer CJ, Gu D. A polygenic risk score improves risk stratification of coronary artery disease: a large-scale prospective Chinese cohort study. Eur Heart J. 2022 May 7;43(18):1702-1711. doi: 10.1093/eurheartj/ehac093. PMID: 35195259; PMCID: PMC9076396.

2.    Zhao K, Shen X, Liu H, Lin Z, Li J, Chen S, Liu F, Huang K, Cao J, Liu X, Shen C, Yu L, Zhao Y, Zhao L, Li Y, Hu D, Huang J, Lu X, Gu D. Somatic and Germline Variants and Coronary Heart Disease in a Chinese Population. JAMA Cardiol. 2024 Mar 1;9(3):233-242. doi: 10.1001/jamacardio.2023.5095. PMID: 38198131; PMCID: PMC10782380.

3.    Liang F, Liu F, Huang K, Yang X, Li J, Xiao Q, Chen J, Liu X, Cao J, Shen C, Yu L, Lu F, Wu X, Wu X, Li Y, Hu D, Huang J, Liu Y, Lu X and Gu D*. Long-Term Exposure to Fine Particulate Matter and Cardiovascular Disease in China. J Am Coll Cardiol. 2020;75:707-717.

4.    Liang F, Xiao Q, Huang K, Yang X, Liu F, Li J, Lu X, Liu Y, Gu D. The 17-y spatiotemporal trend of PM2.5 and its mortality burden in China. Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25601-25608. doi: 10.1073/pnas.1919641117. Epub 2020 Sep 21. PMID: 32958653; PMCID: PMC7568266.

5.    Lu X, Niu X, Shen C, Liu F, Liu Z, Huang K, Wang L, Li J, Hu D, Zhao Y, Yang X, Lu F, Liu X, Cao J, Chen S, Li H, Tang W, Ren Z, Yu L, Wu X, Wu X, Li Y, Zhang H, Huang J, Hu Z, Shen H, Willer CJ, Gu D. Development and Validation of a Polygenic Risk Score for Stroke in the Chinese Population. Neurology. 2021 Aug 10;97(6):e619-e628. doi: 10.1212/WNL.0000000000012263. Epub 2021 May 24. PMID: 34031205; PMCID: PMC8424497.

6.    Li J, Lu X, Liu F, Liang F, Huang K, Yang X, Xiao Q, Chen J, Liu X, Cao J, Chen S, Shen C, Yu L, Lu F, Wu X, Zhao L, Wu X, Li Y, Hu D, Huang J, Zhu M, Liu Y, Shen H, Gu D. Chronic Effects of High Fine Particulate Matter Exposure on Lung Cancer in China. Am J Respir Crit Care Med. 2020 Dec 1;202(11):1551-1559. doi: 10.1164/rccm.202001-0002OC. PMID: 32614242; PMCID: PMC8168622.

7.    Liu Q, Liu F, Li J, Huang K, Yang X, Chen J, Liu X, Cao J, Shen C, Yu L, Zhao Y, Wu X, Zhao L, Li Y, Hu D, Lu X, Huang J, Gu D. Sedentary behavior and risk of incident cardiovascular disease among Chinese adults. Sci Bull. 2020 Oct 30;65(20):1760-1766. doi: 10.1016/j.scib.2020.05.029. Epub 2020 May 30. PMID: 36659249.

8.    Li J, Huang K, Li J, Liang F, Chen S, Cao J, Yang X, Shen C, Zhao L, Li Y, Hu D, Huang J, Liu Y, Lu X, Liu F, Gu D. Long-term Fine Particulate Matter Exposure and Coronary Artery Disease: Unraveling Cardiometabolic Pathways and Modification of Genetic Susceptibility. Eur J Prev Cardiol. 2025 Apr 24:zwaf239. doi: 10.1093/eurjpc/zwaf239. PMID: 40273389.

9.    Li X, Wang S, Wu K, Mo C, Li F, Cheng Z, Liang F, Zheng J, Gu D. Time-dependent cardiovascular risks following pneumonia in inpatient and outpatient settings: A register-based cohort study. Int J Cardiol Cardiovasc Risk Prev. 2024 Aug 6;22:200317. doi: 10.1016/j.ijcrp.2024.200317. PMID: 39224118; PMCID: PMC11366901.

10.  Han M, Huang K, Shen C, Hu H, Liu F, Li J, Yang X, Chen J, Liu X, Cao J, Chen S, Yu L, Zhao Y, Wu X, Zhao L, Li Y, Hu D, Huang J, Lu X, Gu D. Discordant High Remnant Cholesterol With LDL-C Increases the Risk of Stroke: A Chinese Prospective Cohort Study. Stroke. 2024 Aug;55(8):2066-2074. doi: 10.1161/STROKEAHA.124.046811. Epub 2024 Jul 22. PMID: 39038095.

11.  Liang F, Yang X, Peng W, Zhen S, Cao W, Li Q, Xiao Z, Gong M, Wang Y, Gu D. Applications of digital health approaches for cardiometabolic diseases prevention and management in the Western Pacific region. Lancet Reg Health West Pac. 2023 Dec 1;43:100817. doi: 10.1016/j.lanwpc.2023.100817. PMID: 38456090; PMCID: PMC10920052.

12.  Ma H, Liu F, Li J, Chen J, Cao J, Chen S, Liu X, Yang X, Huang K, Shen C, Yu L, Zhao Y, Wu X, Zhao L, Li Y, Hu D, Huang J, Lu X, Gu D. Sex Differences in Associations Between Socioeconomic Status and Incident Hypertension Among Chinese Adults. Hypertension. 2023 Apr;80(4):783-791. doi: 10.1161/HYPERTENSIONAHA.122.20061. Epub 2023 Jan 25. PMID: 36695186.

13.  Li FR, Wang S, Li X, Cheng ZY, Jin C, Mo CB, Zheng J, Liang FC, Gu DF. Multimorbidity and mortality among older patients with coronary heart disease in Shenzhen, China. J Geriatr Cardiol. 2024 Jan 28;21(1):81-89. doi: 10.26599/1671-5411.2024.01.005. PMID: 38440336; PMCID: PMC10908585.

14.  Yuan C, Liu F, Huang K, Shen C, Li J, Liang F, Yang X, Cao J, Chen S, Hu D, Huang J, Liu Y, Lu X, Gu D. Association of Long-Term Exposure to Ambient Fine Particulate Matter with Atherosclerotic Cardiovascular Disease Incidence Varies across Populations with Different Predicted Risks: The China-PAR Project. Environ Sci Technol. 2023 Jul 11;57(27):9934-9942. doi: 10.1021/acs.est.3c01460. Epub 2023 Jun 27. PMID: 37368969.

15.  Jin C, Li J, Liu F, Li X, Hui Y, Chen S, Li F, Wang G, Liang F, Lu X, Wu S, Gu D. Life's Essential 8 and 10-Year and Lifetime Risk of Atherosclerotic Cardiovascular Disease in China. Am J Prev Med. 2023 Jun;64(6):927-935. doi: 10.1016/j.amepre.2023.01.009. Epub 2023 Feb 20. PMID: 36813641.

16.  Cui Q, Liu Z, Li J, Liu F, Niu X, Shen C, Hu D, Huang K, Chen S, Zhao Y, Lu F, Liu X, Cao J, Wang L, Ma H, Yu L, Wu X, Li Y, Zhang H, Mo X, Zhao L, Hu Z, Shen H, Huang J, Lu X, Gu D. Impact of cardiovascular health and genetic risk on coronary artery disease in Chinese adults. Heart. 2023 Apr 25;109(10):756-762. doi: 10.1136/heartjnl-2022-321657. PMID: 36539268.

17.  Li J, Liang F, Liu F, Li J, Huang K, Yang X, Chen S, Cao J, Shen C, Zhao L, Li Y, Hu D, Wang W, Wu J, Huang J, Lu X, Gu D. Genetic risk modifies the effect of long-term fine particulate matter exposure on coronary artery disease. Environ Int. 2022 Dec;170:107624. doi: 10.1016/j.envint.2022.107624. Epub 2022 Nov 10. PMID: 36402033.

18.  Liu F, Liu F, Lin J, Wang J, Chen J, Li J, Huang J, Hu D, Lu X, Sun X, Gu D. The Early Impact of the People-centred Integrated Care on the Hypertension Management in Shenzhen. Int J Integr Care. 2023 Feb 6;23(1):6. doi: 10.5334/ijic.6539. PMID: 36819616; PMCID: PMC9912848.

19.  Lin Y, Liu Q, Liu F, Huang K, Li J, Yang X, Wang X, Chen J, Liu X, Cao J, Shen C, Yu L, Lu F, Wu X, Zhao L, Li Y, Hu D, Lu X, Huang J, Gu D. Adverse associations of sedentary behavior with cancer incidence and all-cause mortality: A prospective cohort study. J Sport Health Sci. 2021 Sep;10(5):560-569. doi: 10.1016/j.jshs.2021.04.002. Epub 2021 Apr 18. PMID: 33878448; PMCID: PMC8500832.

20.  He J, Huang JF, Li C, Chen J, Lu X, Chen JC, He H, Li JX, Cao J, Chen CS, Bazzano LA, Hu D, Kelly TN, Gu DF. Sodium Sensitivity, Sodium Resistance, and Incidence of Hypertension: A Longitudinal Follow-Up Study of Dietary Sodium Intervention. Hypertension. 2021 Jul;78(1):155-164. doi: 10.1161/HYPERTENSIONAHA.120.16758. Epub 2021 Apr 26. PMID: 33896191; PMCID: PMC8192427.

21.  Huang S, Zhang X, Huang J, Lu X, Liu F, Gu D. Ambient air pollution and body weight status in adults: A systematic review and meta-analysis. Environ Pollut. 2020 Oct;265(Pt A):114999. doi: 10.1016/j.envpol.2020.114999. Epub 2020 Jun 13. PMID: 32806418.

22.  Huang K, Liang F, Yang X, Liu F, Li J, Xiao Q, Chen J, Liu X, Cao J, Shen C, Yu L, Lu F, Wu X, Zhao L, Wu X, Li Y, Hu D, Huang J, Liu Y, Lu X and Gu D*. Long term exposure to ambient fine particulate matter and incidence of stroke: prospective cohort study from the China-PAR project. BMJ. 2019;367:l6720.

23.  Gu D*, et al. Chinese guideline on healthy lifestyle to prevent cardiometabolic diseases. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 2020;54:256-277.

24.  Xia X, Liu F, Yang X, Li J, Chen J, Liu X, Cao J, Shen C, Yu L, Zhao Y, Wu X, Zhao L, Li Y, Huang J, Lu X, Gu D*. Associations of egg consumption with incident cardiovascular disease and all-cause mortality. Sci China Life Sci. 2020 Sep;63(9):1317-1327.

25.  Wang X, Liu F, Li J, Yang X, Chen J, Cao J, Wu X, Lu X, Huang J, Li Y, Zhao L, Shen C, Hu D, Yu L, Liu X, Wu X, Wu S and Gu D*. Tea consumption and the risk of atherosclerotic cardiovascular disease and all-cause mortality: The China-PAR project. Eur J Prev Cardiol. 2020:2047487319894685.

26.  Yang X, Liang F, Li J, Chen J, Liu F, Huang K, Cao J, Chen S, Xiao Q, Liu X, Shen C, Yu L, Lu F, Wu X, Wu X, Li Y, Zhao L, Hu D, Huang J, Lu X, Liu Y* and Gu D*. Associations of long-term exposure to ambient PM2.5 with mortality in Chinese adults: A pooled analysis of cohorts in the China-PAR project. Environment international. 2020;138:105589.

27. Liu Q, Liu FC, Huang KY, Li JX, Yang XL, Wang XY, Chen JC, Liu XQ, Cao J, Shen C, Yu L, Lu FH, Wu XP, Zhao LC, Li Y, Hu DS, Lu XF, Huang JF and Gu D*. Beneficial effects of moderate to vigorous physical activity on cardiovascular disease among Chinese adults. J Geriatr Cardiol. 2020;17:85-95.