Profile:

Dr. BAI, holding a Ph.D. in Cardiovascular Biomedicine from the University of Hong Kong and a postdoctoral fellowship from the Agency for Science, Technology and Research (A*STAR) in Singapore, currently serves as an Assistant Research Professor at the School of Public Health and Emergency Management, Southern University of Science and Technology. Dr. BAI has long been engaged in basic and clinical research on cardiovascular diseases, including molecular mechanisms underlying endothelial aging, coronary heart disease, and heart failure. As a first or co-author, Dr. BAI has published 24 SCI-indexed papers, with over 900 citations and an h-index of 16. Representative works have been published in journals such as Circulation, JACC: Basic to Translational Science, and British Journal of Pharmacology, and have been highlighted by the Circulation editorial board and the International Atherosclerosis Society. Dr. BAI currently leads one general project funded by the National Natural Science Foundation of China and two general projects funded by the Natural Science Foundation of Guangdong Province. Additionally, Dr. BAI serves as a peer reviewer for the National Natural Science Foundation of China, as well as for natural science foundations in Beijing and Guangdong Province, and for journals including Journal of Advanced Research, Cardiovascular Diagnosis and Therapy, and Pharmacological Research. In 2020, Dr. BAI was recognized as a Category C High-Level Overseas Talent by the City of Shenzhen (tenure: 2020–2025).

Funding awarded:

1.    National Natural Science Foundation of China, General Project (No. 82270266), ¥520,000, 2023–2026, PI.

2.    Guangdong Basic and Applied Basic Research Foundation, General Project (No. 2024A1515012491), ¥150,000, 2024–2026, PI.

3.    Guangdong Basic and Applied Basic Research Foundation, General Project (No. 2021A1515010696), ¥100,000, 2021–2023, PI.

4.    Shenzhen Second People's Hospital "High-Level Hospital Construction Research Start-Up Fund," ¥300,000, 2019–2022, PI.

Selected Publications:

1. Bo BAI, Yun Xu, Haibo Chen. Pathogenic roles of neutrophil-derived alarmins (S100A8/A9) in heart failure: from molecular mechanisms to therapeutic insights. British Journal of Pharmacology, 2023,180(5):573-588.

2. Bo BAI, Min Cheng, Lingyan Jiang, et al. High neutrophil to lymphocyte ratio and its gene signatures correlates with diastolic dysfunction in heart failure with preserved ejection fraction. Frontiers in Cardiovascular Medicine, 2021, 8: 614757.

3. Bo BAI, Haibo Chen. Metformin: A novel weapon against inflammation. Frontiers in Pharmacology, 2021, 12: 622262 （Citation>130）

4. Bo BAI, Meng Zhang, Yihao Zhuang, et al. The pregnancy-associated spontaneous coronary artery dissection in a young woman with a novel missense mutation in NOTCH1: a case report. BMC medical genetics, 2020, 21(119):1-8

5. Bo BAI, Wulin Yang, Yanyun Fu, et al. Seipin knockout mice develop heart failure with preserved ejection fraction. JACC: Basic to Translational Science, 2019, 4(8):924-937. Editorial comments: JACC: Basic to Translational Science, 2019, 4(8): 938-939.

6. YM Guo, Yu Wang, Bo BAI, CDK5, Encyclopedia of signaling molecules, 2018, Springer Science Press, ISBN 978-3-319-67200-7.

7. AW Man, Bo BAI, Yu Wang, Cloning and characterization of sirtuin3 (SIRT3), Methods in Molecular Biology, 2016, Springer Science Press, ISSN: 1064-3745.

8. Bo BAI, Vanhoutte PM, Yu Wang, Loss of SIRT1 function during vascular ageing: hyperphosphorylation mediated by cyclin-dependent kinase 5. Trends in Cardiovascular Medicine, 2014, 24(2): 81-84

9. Bo BAI, Yu Wang, Methods to investigate the role of SIRT1 in endothelial senescence, Methods in Molecular Biology, 2012, Springer Science Press, ISSN: 1064-3745.

10. Bo BAI, Yan Liang, Cheng Xu, et al, Cyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis. Circulation, 2012, 126(6):729-740.

Editorial comments: The most read articles on topics of vascular medicine and atherosclerosis. Circulation, 2013;128:e220-234, e328-335. Highlighted by the Asia-Pacific International Molecular Biology Network (A-IMBN) and International Atherosclerosis Society (www.athero.org) （Citation>110）

11. Bo BAI, Yu Wang. The use of lorcaserin in the management of obesity: a critical appraisal. Drug Design, Development and Therapy, 2011, 5: 1-7