PROFILE

Dr. Zhang received his doctoral degree from Nanjing Medical University and subsequently completed postdoctoral training at the Southern University of Science and Technology (SUSTech). She currently serves as a Research Assistant Professor in Professor Gu Dongfeng's research group at SUSTech's School of Public Health and Emergency Management, where her primary research focuses on fundamental studies of cardiovascular diseases. Dr. Zhang was designated as a Shenzhen High-Level Talent in August 2021.

RESEARCH DIRECTIONS

1.Focus on cardiovascular genomics, using whole-genome sequencing data and gene editing to elucidate disease mechanisms and therapeutic targets.

2.Postdoctoral work focused on cancer metastasis research by establishing a mouse model of lung-specific prostate cancer metastasis. Screening organism-specific target genes for mechanistic investigation.

EDUCATION

1.Ph.D. in Medicine (2012.09–2017.06)，Key Lab of Xenotransplantation, Jiangsu Province，Nanjing Medical University, China

2.B.Sc. (2007.09–2011.06)，Xinjiang Agricultural University, China.

VISITING TRAINING

1.hESCs Culture (Jul–Aug 2014): CITIC-Xiangya Reproductive & Genetic Hospital.

2.iPSCs Technology (Mar–May 2014): National University of Singapore.

3.CRISPR/Cas9 (Sep–Oct 2013): Guangzhou Institutes of Biomedicine and Health, CAS

WORK EXPERIENCE

1. Research Assistant Professor (2022–Present), School of Public Health and Emergency Management, SUSTech

2. Assistant Researcher (2020–2022), School of Medicine, SUSTech

3. Postdoctoral Fellow (2017–2020), School of Medicine, SUSTech

MEMBERS

1. Member of the American Association for Cancer Research (AACR)

2. Member of the Tumor Metastasis Professional Committee, Chinese Anti-Cancer Association

GRANTS & PROJECTS

1. Molecular Mechanism of CCDC92 in Atherosclerosis Development, supported by Shenzhen Technology and Innovation Commission.

2. Molecular Mechanism of SMC4 in Promoting Prostate Cancer Metastasis, supported by National Natural Science Foundation of China (NSFC).

PAPERS

1. Wei Zhang#, Siyuan Qin#, Xiaokang Li#, Ming Chang, Tianzi Wei, Xin Huang, Haibo Tong, Xia Guo*, Yi Lu*, Jian Zhang*. SMC4 Promotes Prostate Cancer Cell Proliferation and Metastasis via the Rheb/mTOR Pathway. Advanced Science. 2025 Jun;12(23):e2500369. 

2. Wei Zhang#, Xiaokang Li#, Uet Yu, Xin Huang, Hongmei Wang, Yi Lu*, Sixi Liu*, Jian Zhang*. Genome-wide methylation and gene-expression analyses in thalassemia. Aging-US. 2024 Aug 9;16(15):11591-11605.

3. Xinyang Li# , Wei Zhang# , Yu Shu# , Rui Huo, Chengyang Zheng, Qi Qi, Pengfei Fu, Jie Sun, Yuhuan Wang, Yan Wang, Juxu Lu, Xiangjie Zhao, Guoyou Yin, Qingqing Wang, Jun Hong. Biparatopic anti-PCSK9 antibody enhances the LDL-uptake in HepG2 cells. Scientific Reports. 2024 Jul 3; 14(1):15331.

4. Wei Zhang#, Xiaokang Li#, Xiaoxia Wu#, Xin Huang, Xiao Zhang, Yi Lu, Jianmin Niu, Jian Zhang*. Whole-exome sequencing analysis of amniotic fluid cells in 5 pregnant women with thalassemia Case report. Medicine. 2022. 101:47.

5. Haixia Han, Rui Ma, Aidi Xie, Juanjuan Gao, Zhen Wang, Yi Zhao,Huanming Pang, Wei Zhang* Development of an LC/MS/MS Method for Simultaneous Detection of 11 Polyphenols in Rat Plasma and Its Pharmacokinetic Application after Oral Administration of Coreopsis tinctoria Extract. Chemistry & Biodiversity. 2023 Jan;20(1):e202200574.

6. Wei Yu, Xiao Zhang, Wei Zhang, Minggang Xiong, Yuhan Lin, Ming Chang, Lin Xu, Yi Lu*, Yun Liu*, Jian Zhang*. 19-Hydroxybufalin inhibits non-small 1 cell lung cancer cell 2 proliferation and promotes cell apoptosis via the Wnt/β-catenin pathway. Experimental Hematology & Oncology. 2021 Oct 25;10(1):48.

7. Wei Zhang#, Guan Wang#, Ying Wang#,Yong Jin, Lihua Zhao, Qiang Xiong, Lining Zhang, LishaMou, Rongfeng Li, HaiYuan Yang*, Yifan Dai*. Generation of complement protein C3 deficient pigs by CRISPR/Cas9-mediated gene targeting, Scientific Reports, 2017, 7:5009.

8. Fengjiao Chen#, Ying Wang#, Yilin Yuan，Wei Zhang, Zijian Ren, Yong Jin, Xiaorui Liu, Qiang Xiong, Qin Chen, Manling Zhang, Xiaokang Li, Lihua Zhao, Ze Li, Zhaoqiang Wu, Yanfei Zhang, Feifei Hu, Juan Huang, Rongfeng Li*, Yifan Dai*. Generation of B Cell-Deficient Pigs by Highly Efficient CRISPR/Cas9- Mediated Gene Targeting, Journal of Genetics and Genomics, 2015, 42:437-444.

PATENT

1. Use of an Agent Inhibiting CCDC92 Expression in the Preparation of a Drug for Treating Hyperlipidemia and Atherosclerosis.

2. A Diagnostic Biomarker for β-Thalassemia and Its Applications

PUBLICATION

1.Holisitic intergrative oncology