个人简介

张振锋，公共卫生及应急管理学院助理教授，博士生导师。中国科学院武汉病毒研究所博士，德国海德堡大学博士后，2022年加入南方科技大学。主要从事肝炎病毒、天然免疫、以及抗病毒治疗策略等研究，同时向新发病毒，个体化抗病毒免疫和精准防控等领域拓展。主持国家自然科学基金2项，作为主要成员参与国家自然科学基金国际合作项目、德国科学基金（DFG）重大项目等多项。共发表论文30多篇，其中以第一作者和共同第一作者在Journal of Hepatology（4篇），Journal of Immunology，Viruses等期刊发表论文9篇。研究成果多次被国际学术大会选为口头报告，并获得国际肝病大会、美国肝病学会、国际乙肝病毒大会等授予的多项奖励。担任Viruses杂志客座编辑，Journal of Hepatology, Antiviral research, Viruses, Liver International, Antimicrobial Agents and Chemotherapy等杂志审稿人。

    课题组长期招收硕士生、博士生、博士后、研究助理、和访问学生，欢迎联系。

研究方向

 1. 乙型肝炎病毒和丁型肝炎病毒持续性感染机制和新型感染模型

 2. 乙型肝炎和丁型肝炎的治疗策略（核酸类药物、新型疫苗、靶向治疗等）

 3. 天然免疫抗病毒机制及其在治疗中的应用

 4. 个体化抗病毒免疫形成的机制与病毒精准防治

工作经历

 2022.10-今：         南方科技大学，公共卫生及应急管理学院，助理教授

 2015.09-2022.09：德国海德堡大学，整合传染病研究中心，博士后

                              合作导师：Stephan Urban教授和Ralf Bartenschlager教授

 2012.09-2015.08：中国科学院武汉病毒研究所，助理研究员

                               合作导师：王汉中研究员

教育经历

2004.09 - 2012.07：中国科学院武汉病毒研究所，微生物学，博士

2000.09 – 2004.07：新疆大学，生物技术，本科

部分课题项目

[1]   中国国家自然科学基金面上项目：丁型肝炎病毒在细胞内持续复制及干扰素抗病毒机制研究。2024-2027（主持）

[2]   中国国家自然科学基金国际合作项目：中国和蒙古丁型肝炎流行病学和分子病毒学比较研究及HDV加速肝病进展机制。2024-2026（参与）

[3]   德国科研基金DFG重大项目TRR179: Determinants and dynamics of elimination versus persistence of hepatitis virus infection。第二轮：2020-2024 （参与）

[4]   德国科研基金DFG重大项目SFB1129: Integrative Analysis of Pathogen Replication and Spread。第二轮：2018-2022 （参与）

[5]   德国科研基金DFG重大项目TRR179: Determinants and dynamics of elimination versus persistence of hepatitis virus infection。第一轮：2016-2020 （参与）

[6]   德国科研基金DFG重大项目SFB1129：Integrative Analysis of Pathogen Replication and Spread。第一轮：2014-2018 （参与）

[7]   中国国家自然科学基金面上项目：干扰素刺激蛋白Viperin在EV71神经组织感染中所起作用及其机制。2015-2018（参与）

[8]   中国国家自然科学基金青年项目：人博卡病毒及其NS1蛋白抑制I型干扰素生成的机制。2014-2016（主持）

奖励和荣誉

[1]   国际乙型肝炎病毒大会参会资助Free Registration，2022

[2]   欧洲肝病协会 (EASL) - 国际肝脏大会青年学者资助 (Young Investigator Bursary) ，2021

[3]   美国肝病研究协会年会 (AASLD) 早期职业学者奖 (Early Career Investigator Award) ，2019

[4]   国际乙型肝炎病毒大会参会资助 Travel Grant，2019

[5]   国际乙型肝炎病毒大会最佳口头报告，2019

[6]   国际乙型肝炎病毒大会参会资助 Travel Grant，2018

[7]   国际乙型肝炎病毒大会参会资助 Travel Grant，2016

[8]   武汉市自然科学优秀学术论文二等奖，2013

学术兼职

[1]   2023-2024，Viruses杂志客座编辑

[2]   欧洲肝病协会（EASL）会员，2019至今

[3]   参与组织德国肝病研究协会年会，2019

[4]   独立审稿人: Journal of Hepatology, Antiviral research, Viruses, Liver International, Antimicrobial Agents and Chemotherapy等杂志

代表性论文（#共同一作，*通讯作者）

[1]       Groth C, Maric J, Lázaro I-G, Hofman T, Zhang Z, Ni Y, Keller F, Seufert I, Hofmann M, Neumann-Haefelin C, Sticht C, Rippe K, Urban S, Cerwenka A. Hepatitis D infection induces IFN-β-mediated NK cell activation and TRAIL-dependent cytotoxicity. Frontiers in Immunology. 2023 Dec 8:14:1287367.

[2]       Gillich N#, Zhang Z#, Binder M, Urban S, Bartenschlager R. Effect of variants in LGP2 on MDA5-mediated activation of interferon response and suppression of hepatitis D virus replication. Journal of Hepatology. 2023; 78(1):78-89. (#, 共同第一作者)

[3]       张振锋. 丁型肝炎抗体检测方法比较分析. 临床肝胆病杂. 2023, 39(4) 751-757.

[4]       Zhang Z, Ni Y, Lempp F.A, Walter L, Mutz P, Bartenschlage R, Urban S. Hepatitis D virus-induced interferon response and administered interferons control cell division-mediated virus spread. Journal of Hepatology. 2022; 77(4):957-966.

[5]       Zhang Z, Urban S. New insights into hepatitis D virus persistence: the role of interferon response and implications for upcoming novel therapies. Journal of Hepatology. 2021; 74(3):686-699.

[6]       张振锋, 庄辉. 丁型肝炎实验室诊断研究进展. 中国病毒病杂志, 2021; 11(6):407-413.

[7]       Wang W, Lempp FA, Schlund F, Walter L, Decker CC, Zhang Z, Ni Y, Urban S. Assembly and infection efficacy of hepatitis B virus surface protein exchanges in 8 hepatitis D virus genotype isolates. Journal of Hepatology. 2021; 75(2):311-323.

[8]       Zhang Z, Urban S. Interplay between Hepatitis D Virus and the Interferon Response. Viruses. 2020; 12(11): 1334.

[9]       Ni Y, Zhang Z, Engelskircher L, Verch G, Tu T, Lempp FA, Urban S. Generation and characterization of a stable cell line persistently replicating and secreting the human hepatitis delta virus. Scientific Reports. 2019; volume 9, Article number: 10021.

[10]    Lempp FA, Schlund F, Rieble L, Nussbaum L, Link C, Zhang Z, Ni Y, Stephan Urban. Recapitulation of HDV infection in a fully permissive hepatoma cell line allows efficient drug evaluation. Nature Communications. 2019; 10:2265.

[11]    Zhang Z, Filzmayer C, Ni Y, Mutz P, Sültmann H, Hiet M-S, Vondran F W.R., Bartenschlager R, Urban S. Hepatitis D Virus replication is sensed by MDA5 and induces IFN-β/λ responses in hepatocytes. Journal of Hepatology. 2018; 69(1):25-35.

[12]    Zhang Z, Zehnder B, Damrau C, Urban S. Visualization of hepatitis B virus entry - novel tools and approaches to directly follow virus entry into hepatocytes. FEBS Letters. 2016; 590(13):1915-26.

[13]    Lv C, Lin Y, Liu A, Hong Z, Wen L, Zhang Z, Zhang ZL, Wang H, Pang D. Labeling viral envelope lipids with quantum dots by harnessing the biotinylated lipid-self-inserted cellular membrane. Biomaterials. 2016; 106:69-77.

[14]    Liu Q, Zhang Z, Zheng Z, Zheng C, Liu Y, Hu Q, Ke X, Wang H. Human Bocavirus NS1 and NS1-70 Proteins Inhibit TNF-α-Mediated Activation of NF-κB by targeting p65. Scientific Reports. 2016; 6:28481.

[15]    Li Q, Zheng Z, Liu Y, Zhang Z, Liu Q, Meng J, Ke X, Hu Q, Wang H. 2C Proteins of Enteroviruses Suppress IKKβ Phosphorylation by Recruiting Protein Phosphatase 1. Journal of Virology. 2016; 90(10): 5141-51.

[16]    Liu A, Zhang Z, Sun E, Zheng Z, Zhang ZL, Hu Q, Wang H, Pang D. Simultaneous Visualization of Parental and Progeny Viruses by a Capsid-Specific HaloTag Labeling Strategy. ACS Nano. 2016; 10(1):1147-55.

[17]    Zheng C, Zheng Z, Zhang Z, Meng J, Liu Y, Ke X, Hu Q, Wang H. IFIT5 positively regulates NF-κB signaling through synergizing the recruitment of IκB kinase (IKK) to TGF-β-activated kinase 1 (TAK1). Cellular Signalling. 2015; 27 (12):2343-54.

[18]    Zhang M, Liu Y, Wang P, Guan X, He S, Luo S, Li C, Hu K, Jin W, Du T, Yan Y, Zhang Z, Zheng Z, Wang H, Hu Q. HSV-2 Immediate-Early Protein US1 Inhibits IFN-β Production by Suppressing Association of IRF-3 with IFN-β Promoter. Journal of Immunology. 2015; 194(7):3102-15.

[19]    Xu N, Wang J, Zhang Z, Pang DW, Wang H, Zhang ZL. Anisotropic cell-to-cell spread of vaccinia virus on microgrooved substrate. Biomaterials. 2014; 35(19):5049-55.

[20]    Zhang X, Shu B, Liu X, Zhang Z, Liu Y, Bai B, Hu Q, Mao P, Wang H. Human Astrocytic Cells Support Persistent Coxsackievirus B3 Infection. Journal of Virology. 2013; 87(22):12407-21.

[21]    Zhang F, Zheng Z, Liu SL, Lu W, Zhang Z, Zhang C, Zhou P, Zhang Y, Long G, He Z, Pang DW, Hu Q, Wang H. Self-biotinylation and site-specific double labeling of baculovirus using quantum dots for single-virus in-situ tracking. Biomaterials. 2013; 34(30):7506-18.

[22]    Luo H, Zheng Z, Ke X, Zhang X, Li Q, Liu Y, Bai B, Mao P, Hu Q, Wang H. Human Bocavirus VP2 Upregulates IFN-β Pathway by Inhibiting Ring Finger Protein 125-Mediated Ubiquitination of Retinoic Acid-Inducible Gene-I. Journal of Immunology. 2013; 191(2):660-9.

[23]    Zheng Z, Ke X, Wang M, He S, Li Q, Zheng C, Zhang Z, Liu Y, Wang H. Human microRNA hsa-miR-296-5p suppresses enterovirus 71 replication by targeting the viral genome. Journal of Virology. 2013; 87(10):5645-56. (IF: 6.549)

[24]    Zhang Y, Ke X, Zheng Z, Zhang C, Zhang Z, Zhang F, Hu Q, He Z, Wang H. Encapsulating quantum dots into enveloped virus in living cells for tracking virus infection. ACS Nano. 2013; 7(5):3896-904.

[25]    Li Q, Zhang Z, Zheng Z, Ke X, Luo H, Hu Q, Wang H. Identification and Characterization of Complex Dual Nuclear Localization Signals in Human Bocavirus NP1. Journal of General Virology. 2013; 94 (Pt 6): 1335-42.

[26]    Zhang Z, Zheng Z, Luo H, Meng J, Li H, Li Q, Zhang X, Ke X, Bai B, Mao P, Hu Q, Wang H. Human Bocavirus NP1 Inhibits IFN-β Production by Blocking Association of IFN Regulatory Factor 3 to IFNB Promoter. Journal of Immunology. 2012; 189(3):1144-53.

[27]    Jin M, Zhang Z, Zheng Z, Liu Y, Wang H. Methionine-101 from one strain of H5N1 NS1 protein determines its IFN-antagonizing ability and subcellular distribution pattern. Science China-Life Sciences. 2012; 55(11):933-9.

[28]    Li Y, Kang QS, Sun GP, Su LJ, Zheng Z, Zhang Z, Wang H, He Z, Huang W. Microchip-based immunoassays with application of silicon dioxide nanoparticle film. Analytical and Bioanalytical Chemistry. 2012; 403(8):2449-57.

[29]    Xu N, Zhang  Z, Wang L, Gao B, Pang D, Wang H, Zhang ZL. A microfluidic platform for real-time and in situ monitoring of virus infection process. Biomicrofluidics. 6, 034122 (2012).

[30]    Tao L, Chen J, Zheng Z, Meng J, Zhang Z, Chen Y, Luo H, Li H, Chen Z, Hu Q, Wang H. H5N1 influenza virus-like particles produced by transient expression in mammalian cells induce humoral and cellular immune responses in mice. Canadian Journal of Microbiology. 2012; 58(4):391-401.

[31]    Huang B, Lin Yi, Zhang ZL, Zhuan F, Liu A, Xie M, Tian Z, Zhang Z, Wang H, Pang D. Surface labeling of enveloped viruses assisted by host cells. ACS Chemical Biology. 2012; 7(4):683-8.

[32]    Zhou P, Zheng Z, Lu W, Zhang F, Zhang Z, Pang D, Hu B, He Z, Wang H. Multicolor labeling of living-virus particles in live cells. Angewandte Chemie International Edition. 2012; 51(3):670-4.

[33]    Zheng Z, Li H, Zhang Z, Meng J, Mao D, Bai B, Lu B, Mao P, Hu Q, Wang H. Enterovirus 71 2C protein inhibits TNF-α-mediated activation of NF-κB by suppressing IκB kinase β phosphorylation. Journal of Immunology. 2011; 187(5):2202-12.

[34]    Hu H, Lu X, Tao L, Bai B, Zhang Z, Chen Y, Zheng F, Chen J, Chen Z, Wang H. Induction of specific immune responses by severe acute respiratory syndrome coronavirus spike DNA vaccine with or without interleukin-2 immunization using different vaccination routes in mice. Clinical and Vaccine Immunology. 2007; 14(7):894-901.

[35]    Zhuan F, Zhang Z, Xu D, Si Y, Wang H, Mijit G. Tn7-mediated introduction of DNA into bacmid-cloned pseudorabies virus genome for rapid construction of recombinant viruses. Virologica Sinica. 2007; 22:316-325.

国际会议报告

[1]   Zhang Z, Walter L, Urban S. Generation of a fluorescent HDV reporter replicon using the split GFP system. 2022 International HBV Meeting (Paris, France). Oral presentation.

[2]   Gillich N#, Zhang Z#, Binder M, Urban S, Bartenschlager R. Role of LGP2 in activation of the interferon response and suppression of HDV replication. 2021 International HBV Meeting (Toronto, Canada). Oral presentation. (#, 共同第一作者)

[3]   Zhang Z, Walther T, Lempp FA,  Ni Y, Urban S. IFN response blocks cell division-mediated HDV spread and suppresses HDV persistence synergistically with antivirals targeting de novo infection. 2021 EASL / International Liver Congress. Oral presentation.

[4]   Zhang Z, Walther T, Lempp FA,  Ni Y, Urban S. Synergistic suppression of HDV persistence in vitro by co-treatment with investigational drugs targeting both extracellular and cell-division-mediated spreading pathways. 2019 Liver Meeting - AASLD (Boston, USA). Oral presentation.

[5]   Zhang Z, Walther T, Lempp FA,  Ni Y, Urban S. Synergistic suppression of HDV persistence in vitro by co-treatment with investigational drugs targeting both extracellular and cell-division-mediated spreading pathways. 2019 International HBV Meeting (Melbourne, Australia). Oral presentation.

[6]   Zhang Z, Ni Y, Urban S. Endogenous and exogenous IFN responses suppress HDV persistence during proliferation of hepatocytes in vitro. 2019 EASL / International Liver Congress (Vienna, Austria). Poster.

[7]   Zhang Z, Ni Y, Urban S. IFN response suppresses HDV persistence during hepatocytes proliferation in vitro. 2018 International HBV Meeting (Taormina, Italy). Oral presentation.

[8]   Zhang Z, Mehnert AK, Zehnder B, Bekker C, Seitz S, Bruss V, Urban S. Site-specific labeling of the HBV and HDV envelope using mCherry-S fusion protein. 2017 international HBV meeting (Washington, D.C. USA). Poster.

[9]   Zhang Z, Ni Y, Filzmayer C, Sültmann H, Urban S. Hepatitis D Virus replication induces MDA5 mediated IFN-β/λ responses in immune-competent susceptible cells. 2016 international HBV meeting (Seoul, Korea). Oral presentation.